Activated leukocyte cell adhesion molecule (ALCAM), also known as CD166, is a protein that is expressed on the surface of various cells, including leukocytes, endothelial cells, and tumor cells. ALCAM plays an important role in cell adhesion and signaling, and is involved in several physiological and pathological processes.
In the immune system, ALCAM is important for the migration and activation of leukocytes, such as T cells and natural killer cells. It is also involved in the formation of immunological synapses, which are essential for proper immune function.
In addition to its role in the immune system, ALCAM is also involved in the development and progression of cancer. It has been shown to promote tumor growth and metastasis by facilitating the adhesion and migration of tumor cells. ALCAM has also been found to be overexpressed in several types of cancer, including breast, colon, and lung cancer.
Due to its involvement in immune function and cancer development, ALCAM has been studied as a potential therapeutic target. Antibodies that target ALCAM have been developed and tested in preclinical models of cancer, and have shown promising results in reducing tumor growth and metastasis.
Overall, ALCAM is a protein with diverse functions and is involved in several important physiological and pathological processes, including immune function and cancer development. Further research is needed to fully understand its role in these processes and its potential as a therapeutic target.