Leigh syndrome, first described by Denis Leigh in 1951, is a severe progressive neurometabolic disorder characterized by bilateral symmetric necrotic lesions in subcortical regions of the central nervous system. Originally termed subacute necrotizing encephalomyelopathy, this disorder represents a final common phenotype for various genetic defects affecting energy metabolism.

Leigh syndrome, first described by Denis Leigh in 1951, is a severe progressive neurometabolic disorder characterized by bilateral symmetric necrotic lesions in subcortical regions of the central nervous system. Originally termed subacute necrotizing encephalomyelopathy, this disorder represents a final common phenotype for various genetic defects affecting energy metabolism.

The landscape of eczema treatment is rapidly evolving, with groundbreaking research and innovative therapies offering new hope for patients with this challenging condition. Scientists and medical researchers are making significant strides in understanding the complex mechanisms behind eczema, leading to the development of more targeted and effective treatments. These advances promise to revolutionize how we approach eczema management in the coming years.

In recent weeks, China's pediatric healthcare system has been grappling with a sharp increase in respiratory infections among children, with the human metapneumovirus (HMPV) identified as a significant contributor. The surge in cases has put hospitals, particularly in northern China, under immense pressure as parents seek urgent care for their children.

The intricate relationship between genetics and eczema has become increasingly clear through advanced medical research and genetic studies. Scientists have discovered that multiple genes work in concert to influence both the development and severity of eczema, making it a complex inherited condition that affects millions worldwide.

The landscape of eczema treatment has evolved significantly in recent years, with groundbreaking research leading to innovative therapies and medications. This article explores the latest developments in eczema treatment, offering hope to millions of patients worldwide who struggle with this chronic inflammatory skin condition.

Neonatal jaundice remains one of the most challenging conditions faced by pediatricians and neonatologists worldwide. The precise evaluation and timely management of jaundice can prevent severe complications and ensure optimal outcomes for newborns. This comprehensive guide explores the multifaceted aspects of neonatal hyperbilirubinemia, from basic pathophysiology to advanced management strategies.

Ventricular septal defect represents the most common congenital heart defect, affecting approximately 2-6 per 1000 live births. This condition involves an abnormal opening in the ventricular septum, allowing blood flow between the right and left ventricles, which can lead to significant hemodynamic consequences if left untreated.

Neonatal jaundice remains one of the most challenging conditions faced by pediatricians and neonatologists worldwide. The precise evaluation and timely management of jaundice can prevent severe complications and ensure optimal outcomes for newborns. This comprehensive guide explores the multifaceted aspects of neonatal hyperbilirubinemia, from basic pathophysiology to advanced management strategies.

A detailed clinical guide on the Ballard Scoring System, covering both neuromuscular and physical maturity criteria for accurate gestational age assessment in newborns, including practical examples and alternative methods.