ATP synthesis

The mitochondrion is a critical organelle known as the powerhouse of the cell, where energy conversion occurs to produce ATP, the cell’s primary energy source. This article delves into the mitochondrion’s structure through a detailed diagram and an electron micrograph, highlighting its double-membrane system and the intricate processes within. Sourced from mouse tissue with a magnification of 236,000x, these images provide a comprehensive view of its role in cellular energy production and metabolism.

Leigh syndrome, first described by Denis Leigh in 1951, is a severe progressive neurometabolic disorder characterized by bilateral symmetric necrotic lesions in subcortical regions of the central nervous system. Originally termed subacute necrotizing encephalomyelopathy, this disorder represents a final common phenotype for various genetic defects affecting energy metabolism.