Basal ganglia

The concept of a nucleus spans multiple scientific disciplines, appearing in atomic structure, cellular biology, and neuroscience, as illustrated in this detailed diagram. This image compares the nucleus of a helium atom, a cell, and specific nuclei within the brain, offering a unique perspective on its role across scales. Exploring these representations enhances understanding of fundamental building blocks, cellular function, and neural organization in the central nervous system.

Leigh syndrome, first described by Denis Leigh in 1951, is a severe progressive neurometabolic disorder characterized by bilateral symmetric necrotic lesions in subcortical regions of the central nervous system. Originally termed subacute necrotizing encephalomyelopathy, this disorder represents a final common phenotype for various genetic defects affecting energy metabolism.