neurological symptoms

Leigh syndrome, first described by Denis Leigh in 1951, is a severe progressive neurometabolic disorder characterized by bilateral symmetric necrotic lesions in subcortical regions of the central nervous system. Originally termed subacute necrotizing encephalomyelopathy, this disorder represents a final common phenotype for various genetic defects affecting energy metabolism.

Explore the comprehensive guide to dermatomes, their clinical significance, and practical applications in neurological assessment. Essential knowledge for healthcare professionals in diagnosis and treatment planning.

The spine represents a complex structure where various pathological changes can significantly impact patient quality of life. Understanding the progression from normal disc anatomy to various pathological states is crucial for healthcare providers in diagnosing and treating spinal conditions effectively.