ADAMTS3

The development of the lymphatic vascular system represents a fascinating and complex process that occurs during embryogenesis. Beginning around embryonic day 9.5 (E9.5) in mice and approximately week 6-7 in human embryos, lymphatic endothelial cell (LEC) progenitors emerge from the cardinal vein through a tightly regulated molecular cascade. This process, known as lymphangiogenesis, is orchestrated by key transcription factors, growth factors, and signaling pathways that ensure proper lymphatic vessel formation.